The Herbs of Smoothie Essentials: Vitamin D2 (Ergocalciferol)


Add a boost with Calcium Blend, featuring Vitamin D.

Vitamin D2[1] – Ergocalciferol is a form of vitamin D, also called vitamin D2. It is marketed under various names including Deltalin (Eli Lilly and Company), Drisdol (Sanofi-Synthelabo) and Calcidol (Patrin Pharma). It is created from viosterol, which in turn is created when ultraviolet light activates ergosterol (which is found in fungi).

Ergocalciferol is widely used as a Vitamin D supplement, and a 2011 clinical guideline [2] considers it to be as effective as cholecalciferol (Vitamin D3), which is produced naturally by the skin when it is exposed to ultraviolet light. However there is now conflicting evidence regarding how similarly D2 and D3 behave in the body and whether they are equally potent. Some studies suggest D3 is more potent [3][4], but others have found that they are equally effective [5][6].

In the absence of adequate exposure to sunlight or equivalent light, dietary intake of vitamin D is required for maintenance of health. Vitamin D occurs naturally in fish and fish oils, eggs, liver and dairy products. The amounts naturally present in dairy products are generally inadequate to meet the requirements and vitamin D3 is added to evaporated milk, infant formulas, and to most fresh fluid cow milk solid by dairies.

In addition, vitamin D2 or vitamin D3 is commonly added to margarines, to certain breakfast cereals and to a few other foods. Fortification of milk with vitamin D3 since the 1920s has been credited with the marked reduction in incidence of rickets. [7]

Smoothie Essentials Calcium Blend

Recognized by the FDA as Generally Recognized As Safe (GRAS) [8]

[1] Natural Health Products Ingredients Database – Vitamin D2:

[2] Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). “Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline”. Journal of Clinical Endocrinology & Metabolism 96 (7): 1911. doi:10.1210/jc.2011-0385.

[3] Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). “Evidence that vitamin D3 increases serum25-hydroxyvitamin D more efficiently than does vitamin D2”. The American journal of clinical nutrition 68 (4): 854–858. PMID 9771862.

[4]  Houghton, L.; Vieth, R. (2006). “The case against ergocalciferol (vitamin D2) as a vitamin supplement”. The American Journal of Clinical Nutrition 84 (4): 694–697. PMID 17023693.

[5] Holick, M. F.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W. et al. (2007). “Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D”. Journal of Clinical Endocrinology & Metabolism 93 (3): 677. doi:10.1210/jc.2007-2308.

[6]Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R. et al. (2010).”Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults”. American Journal of Clinical Nutrition 91 (6): 1621–1626. doi:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729

[7] Database of Select Committee on GRAS Substances (SCOGS) Reviews

[8] Generally Recognized As Safe -GRAS No. 95.

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About Smoothie Essentials - ShelleRae

Welcome! I am ShelleRae and I am very excited you are here. I joined the Smoothie Essentials team about 5 years ago now. Always health conscious and into prevention versus medication it seemed natural when the opportunity came up to take on the creation of this blog and the MatchaGT blog as well. As mother to three and surrogate to many more I've practiced much of what I write on sometimes with great success and other times with a bit less. My friends and family are my test kitchen and my facts are most often from WebMD - they seem to have a fairly accurate and conservative approach. The Smoothie Essentials product is a line of boosts that add functionality to one's daily foods without adding flavor or colors. (except for MatchaGT and green blend) making it easy to "hide" them from the finicky eaters we all know and love. From stirring them into yogurts, smoothies, frappes and even juice drinks it all come out with the original flavor being center star.. My inspiration comes from others who also are striving to live a better life through lifestyle changes. More information is available at or by emailing

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